Endocrine Abstracts

The aim of this work was to study the condition of the reproductive system after long-term administration of letrozole followed by its withdrawal in young males and against the background of involutive changes in aging males in a comparative aspect. The experiments were carried out on Wistar rats with an initial age of 5 months and 15 months, which have been gavaged by letrozole every other day at a dose of 1 mg/kg body weight for 3 months and then 2 months after its discontin...

Maternal stress modifies fetal programming of neuroendocrine development and behavior. These effects are mediated by maternal and fetal corticosteroids and opioids. We evaluated an ability of pharmacological prevention of long-term behavioral and hypothalamic–pituitary–adrenal (HPA) disorders in adult rat offspring induced by daily 1 h maternal immobilization during the last gestational week. Dexamethasone (Dex; 0.1 mg/kg per day) or naltrexone (Ntx; 10 mg/kg per day...

One of the most common environmental endocrine disruptor is bisphenol A (BPA), which mimics estrogen effects. Even at low expositional dose, BPA is capable of transferring across the human placenta in active unconjugated form. The purpose of this work was to investigate the long-term effects of low dose BPA introduction to rats during the critical period of sexual differentiation of the brain on the reproductive system and the behavior of F1 offspring. Wistar dams were exposed...